Project Items
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https://app.polarix.io
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https://app.polarix.io
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Provide your bearer token in the
Authorization
header when making requests to protected resources.Example:
Authorization: Bearer ********************
Path Params
version
number
required
Example:
{{version}}
project_id
string
required
Example:
6582ed0344adfe123d04f772
Query Params
section_id
string
optional
Example:
1
nested
boolean
optional
Example:
true
Header Params
x-api-key
string
required
Example:
1234abcd
Accept
string
optional
Example:
application/json
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Request Request Example
Shell
JavaScript
Java
Swift
curl --location -g --request GET 'https://app.polarix.io/api/1.0/projects/6582ed0344adfe123d04f772/items?section_id=1&nested=true' \
--header 'x-api-key: 1234abcd' \
--header 'Accept: application/json'
Responses
🟢200Success — JSON
application/json
Body
array of:
id
integer
required
title
string
required
section_id
integer
required
user_id
integer
required
pos
integer
required
status
string
required
parent_id
null
required
revisions_count
integer
required
prefix
string
required
children
array [object {15}]
required
id
integer
required
title
null
required
section_id
integer
required
user_id
integer
required
pos
integer
required
status
string
required
parent_id
integer
required
revisions_count
integer
required
prefix
string
required
children
array [object {15}]
required
section
object
required
subscription
null
required
contents
array [object {14}]
required
veeva_item
null
required
veeva_item_notes
array[string]
required
section
object
required
id
integer
required
name
string
required
description
null
required
pos
integer
required
project_id
integer
required
parent_id
null
required
children
array [object {7}]
required
subscription
null
required
contents
array [object {14}]
required
id
integer
required
item_id
integer
required
project_country_id
null
required
text
string
required
clean_text
string
required
updated_at
string
required
commentsCount
integer
required
humanReadableUpdatedDate
string
required
comments
array[string]
required
item_content_attachments
array[string]
required
subscription
null
required
project_country
null
required
tags
array[string]
required
reference_groups
array[string]
required
veeva_item
null
required
veeva_item_notes
array[string]
required
subscriptions
array[string]
required
Example
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less than 20,000 people in the US.", "updated_at": "2023-07-31T15:40:25.000000Z", "commentsCount": 0, "humanReadableUpdatedDate": "31 Jul 2023 at 3:40 pm", "comments": [], "item_content_attachments": [], "subscription": null, "project_country": null, "tags": [], "reference_groups": [ { "id": 395, "user_id": 1, "item_content_id": 10, "created_at": "2022-10-18T14:21:35.000000Z", "updated_at": "2022-10-18T14:21:35.000000Z", "deleted_at": null, "references": [ { "id": 447, "attachment_id": 2, "reference_group_id": 395, "user_id": 1, "pos": 419, "created_at": "2021-09-28T09:26:08.000000Z", "updated_at": "2021-09-28T09:26:08.000000Z", "deleted_at": null, "old": true, "annotations": [ { "id": 158591, "attachment_id": 2, "reference_id": 447, "title": null, "bodyValue": null, "motivation": null, "stylesheet_value": null, "source": null, "quadPoints": 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"inkList": null, "subtype": null, "opacity": null, "strokeColor": null, "strokeWidth": null, "nodeIndex": null, "page": 0, "top": 0, "right": 0, "bottom": 0, "left": 0, "created_at_unix": 1688228254, "updated_at_unix": 1688228254, "user": null } ], "attachment": { "id": 2, "name": "Grech 2020 Cureus", "user_id": 1, "project_id": 1, "file": "https://sf.polarix.io/60913764ab5e8.pdf", "type": "pdf", "is_reference": 1, "contents": null, "pin": 0, "veeva_document_id": null, "initial_veeva_sync": 0, "created_at": "2021-05-04T12:00:36.000000Z", "updated_at": "2021-05-04T12:00:36.000000Z", "deleted_at": null, "reference_uses": 6, "created_at_formatted": "05/04/2021 12:05", "veeva_document": null } } ] } ] } ], "veeva_item": null, "veeva_item_notes": [] }, { "id": 11, "title": null, "section_id": 11, "user_id": 1, "pos": 1, "status": "pending", "parent_id": 9, "revisions_count": 2, "prefix": "1.1.2", "children": [], "section": { "id": 11, "name": "Scientific Statement", "description": null, "pos": 0, "project_id": 1, "parent_id": 10, "children": [] }, "subscription": null, "contents": [ { "id": 11, "item_id": 11, "project_country_id": null, "text": "<a href=\"javascript:void(0);\" id=\"393\" class=\"\">Although Glioblastoma is a rare disease, it is the most common primary brain tumor in adults, representing 77–81% of all primary malignant tumors of the central nervous system (<strike id=\"671\">CNS</strike>).</a>", "clean_text": "Although Glioblastoma is a rare disease, it is the most common primary brain tumor in adults, representing 77–81% of all primary malignant tumors of the central nervous system (CNS).", "updated_at": "2023-07-10T13:37:28.000000Z", "commentsCount": 0, "humanReadableUpdatedDate": "10 Jul 2023 at 1:37 pm", "comments": [], "item_content_attachments": [], "subscription": null, "project_country": null, "tags": [], "reference_groups": [ { "id": 393, "user_id": 4, "item_content_id": 11, "created_at": "2022-10-18T14:21:35.000000Z", "updated_at": "2022-10-18T14:21:35.000000Z", "deleted_at": null, "references": [ { "id": 445, "attachment_id": 5, "reference_group_id": 393, "user_id": 4, "pos": 417, "created_at": "2021-09-14T18:27:37.000000Z", "updated_at": "2021-09-14T18:27:37.000000Z", "deleted_at": null, "old": true, "annotations": [ { "id": 158589, "attachment_id": 5, "reference_id": 445, "title": null, "bodyValue": null, "motivation": null, "stylesheet_value": null, "source": null, "quadPoints": 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"project_id": 1, "parent_id": 10, "children": [] }, "subscription": null, "contents": [ { "id": 12, "item_id": 12, "project_country_id": null, "text": "The incidence of glioblastoma ranges from 0.59 to 5 per 100,000 persons and is on the rise in many countries", "clean_text": "The incidence of glioblastoma ranges from 0.59 to 5 per 100,000 persons and is on the rise in many countries", "updated_at": "2023-06-13T16:33:20.000000Z", "commentsCount": 0, "humanReadableUpdatedDate": "13 Jun 2023 at 4:33 pm", "comments": [], "item_content_attachments": [], "subscription": null, "project_country": null, "tags": [], "reference_groups": [] } ], "veeva_item": null, "veeva_item_notes": [] }, { "id": 13, "title": null, "section_id": 11, "user_id": 1, "pos": 3, "status": "pending", "parent_id": 9, "revisions_count": 1, "prefix": "1.1.4", "children": [], "section": { "id": 11, "name": "Scientific Statement", "description": null, "pos": 0, "project_id": 1, "parent_id": 10, "children": [] }, "subscription": null, "contents": [ { "id": 13, "item_id": 13, "project_country_id": null, "text": "The average annual age-adjusted incidence rate of glioblastoma in the US, based on the 2013 Central Brain Tumor Registry of the United States report, is 3.19/100,000 population - WHO", "clean_text": "The average annual age-adjusted incidence rate of glioblastoma in the US, based on the 2013 Central Brain Tumor Registry of the United States report, is 3.19/100,000 population - WHO", "updated_at": "2023-06-13T16:33:20.000000Z", "commentsCount": 0, "humanReadableUpdatedDate": "13 Jun 2023 at 4:33 pm", "comments": [], "item_content_attachments": [], "subscription": null, "project_country": null, "tags": [], "reference_groups": [ { "id": 402, "user_id": 1, "item_content_id": 13, "created_at": "2022-10-18T14:21:36.000000Z", "updated_at": "2022-10-18T14:21:36.000000Z", "deleted_at": null, "references": [ { "id": 455, "attachment_id": 12, "reference_group_id": 402, "user_id": 1, "pos": 426, "created_at": "2021-11-09T12:18:39.000000Z", "updated_at": "2021-11-09T12:18:39.000000Z", "deleted_at": null, "old": true, "annotations": [ { "id": 158597, "attachment_id": 12, "reference_id": 455, "title": null, "bodyValue": null, "motivation": null, "stylesheet_value": null, "source": null, "quadPoints": 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Statement", "description": null, "pos": 0, "project_id": 1, "parent_id": 10, "children": [] }, "subscription": null, "contents": [ { "id": 14, "item_id": 14, "project_country_id": null, "text": "<a href=\"javascript:void(0);\" id=\"397\" class=\"\">Glioblastomas</a> tend to affect older individuals (age 45 to 70) and occurs only rarely in children. Nearly half of patients with newly diagnosed glioblastoma are > 65 years old, and this number is expected to increase in many developed nations where the population is aging. Add some content", "clean_text": "Glioblastomas tend to affect older individuals (age 45 to 70) and occurs only rarely in children. Nearly half of patients with newly diagnosed glioblastoma are > 65 years old, and this number is expected to increase in many developed nations where the population is aging. Add some content", "updated_at": "2023-06-13T16:33:20.000000Z", "commentsCount": 0, "humanReadableUpdatedDate": "13 Jun 2023 at 4:33 pm", "comments": [], "item_content_attachments": [], "subscription": null, "project_country": null, "tags": [], "reference_groups": [ { "id": 397, "user_id": 1, "item_content_id": 14, "created_at": "2022-10-18T14:21:35.000000Z", "updated_at": "2022-10-18T14:21:35.000000Z", "deleted_at": null, "references": [ { "id": 449, "attachment_id": 10, "reference_group_id": 397, "user_id": 1, "pos": 421, "created_at": "2021-10-14T16:28:49.000000Z", "updated_at": "2021-10-14T16:28:49.000000Z", "deleted_at": null, "old": true, "annotations": [ { "id": 158592, "attachment_id": 10, "reference_id": 449, "title": null, "bodyValue": null, "motivation": null, "stylesheet_value": null, "source": null, "quadPoints": 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null, "pos": 0, "project_id": 1, "parent_id": 10, "children": [] }, "subscription": null, "contents": [ { "id": 15, "item_id": 15, "project_country_id": null, "text": "<a href=\"javascript:void(0);\" id=\"5386\" class=\"\">A higher incidence of glioblastoma is observed in Caucasians when compared with Africans and African-Americans, and a lower incidence is reported in Asians and Native Americans.</a>", "clean_text": "A higher incidence of glioblastoma is observed in Caucasians when compared with Africans and African-Americans, and a lower incidence is reported in Asians and Native Americans.", "updated_at": "2023-07-11T11:13:27.000000Z", "commentsCount": 0, "humanReadableUpdatedDate": "11 Jul 2023 at 11:13 am", "comments": [], "item_content_attachments": [], "subscription": null, "project_country": null, "tags": [], "reference_groups": [ { "id": 5386, "user_id": 72, "item_content_id": 15, "created_at": "2023-07-11T11:09:57.000000Z", "updated_at": "2023-07-11T11:09:57.000000Z", 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tendance à affecter les personnes âgées. ", "clean_text": "Bien qu’il s’agisse d’un type commun de tumeur cérébrale, le glioblastome est une maladie orpheline qui a tendance à affecter les personnes âgées. ", "updated_at": "2023-07-10T14:55:56.000000Z", "commentsCount": 0, "humanReadableUpdatedDate": "10 Jul 2023 at 2:55 pm", "comments": [], "item_content_attachments": [], "subscription": null, "project_country": { "id": 3, "project_id": 1, "country_id": 73, "deadline": null, "auth_code": null, "created_at": "2023-03-31T11:01:38.000000Z", "updated_at": "2023-03-31T11:01:38.000000Z", "deleted_at": null, "deadline_expired": false, "country": { "id": 73, "code": "FR", "name": "France", "prefix": 33, "created_at": "2022-10-18T14:22:06.000000Z", "updated_at": "2022-10-18T14:22:06.000000Z", "deleted_at": null }, "team": { "id": 15, "name": "France", "label": "FR", "project_id": 1, "project_country_id": 3, "team_users": [] } }, "tags": [], "reference_groups": [] } ], "veeva_item": null, "veeva_item_notes": [] }, { "id": 2, "title": null, "section_id": 10, "user_id": 1, "pos": 1, "status": "pending", "parent_id": 1, "revisions_count": 6, "prefix": "1.2", "children": [ { "id": 3, "title": null, "section_id": 11, "user_id": 1, "pos": 0, "status": "pending", "parent_id": 2, "revisions_count": 11, "prefix": "1.2.1", "children": [], "section": { "id": 11, "name": "Scientific Statement", "description": null, "pos": 0, "project_id": 1, "parent_id": 10, "children": [] }, "subscription": null, "contents": [ { "id": 3, "item_id": 3, "project_country_id": null, "text": "<p><a href=\"javascript:void(0);\" id=\"2582\" class=\"\">Glioblastomas originate from a type of glial cell called the <i>astrocyte</i></a>. They often first appear as <strike id=\"103\">WHO</strike> designated grade IV (rapidly growing and aggressive) tumors with no evidence of earlier lower grade tumors.</p>", "clean_text": "Glioblastomas originate from a type of glial cell called the astrocyte. They often first appear as WHO designated grade IV (rapidly growing and aggressive) tumors with no evidence of earlier lower grade tumors.", "updated_at": "2023-06-13T16:33:20.000000Z", "commentsCount": 0, "humanReadableUpdatedDate": "13 Jun 2023 at 4:33 pm", "comments": [], "item_content_attachments": [ { "id": 123, "item_content_id": 3, "attachment_id": 2987, "user_id": 72, "pos": 0, "created_at": "2023-03-21T11:47:28.000000Z", "updated_at": "2023-03-21T11:47:28.000000Z", "deleted_at": null, "attachment": { "id": 2987, "name": "1.1.1 Glioblastoma", "user_id": 72, "project_id": 1, "file": "https://sf.polarix.io/6419994f9f85c.png", "type": "image", "is_reference": 0, "contents": null, "pin": 0, "veeva_document_id": null, "initial_veeva_sync": 0, "created_at": "2023-03-21T11:47:27.000000Z", "updated_at": "2023-03-21T11:47:27.000000Z", "deleted_at": null, "reference_uses": 0, "created_at_formatted": "03/21/2023 11:03", "veeva_document": null } }, { "id": 124, "item_content_id": 3, 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"reference_groups": [ { "id": 2582, "user_id": 72, "item_content_id": 3, "created_at": "2023-03-21T11:27:16.000000Z", "updated_at": "2023-03-21T11:27:16.000000Z", "deleted_at": null, "references": [ { "id": 5708, "attachment_id": 5, "reference_group_id": 2582, "user_id": 72, "pos": 5503, "created_at": "2023-03-21T11:27:16.000000Z", "updated_at": "2023-03-21T11:27:16.000000Z", "deleted_at": null, "old": false, "annotations": [ { "id": 147924, "attachment_id": 5, "reference_id": 5708, "title": null, "bodyValue": null, "motivation": "commenting", "stylesheet_value": "body-value-css { font: 12px Helvetica; color: #000000;}", "source": "attachment-5", "quadPoints": "[311.3333333333333,606.3333333333334,554,606.3333333333334,311.3333333333333,596.3333333333334,554,596.3333333333334,311.3333333333333,595,554.6666666666666,595,311.3333333333333,585,554.6666666666666,585,311.3333333333333,584.3333333333334,347.3333333333333,584.3333333333334,311.3333333333333,574.3333333333334,347.3333333333333,574.3333333333334]", "inkList": null, "subtype": "highlight", "opacity": 1, "strokeColor": "#F8D147", "strokeWidth": null, "nodeIndex": 0, "page": 0, "top": 311.33333333333, "right": 574.33333333333, "bottom": 554.66666666667, "left": 606.33333333333, "created_at_unix": 1679398036, "updated_at_unix": 1679398036, "user": { "name": "Annika Voss", "user_id": 72, "annotation_id": 147924, "app": "polarix" } } ], "attachment": { "id": 5, "name": "Kim 2018", "user_id": 1, "project_id": 1, "file": "https://sf.polarix.io/609137655fc2a.pdf", "type": "pdf", "is_reference": 1, "contents": null, "pin": 0, "veeva_document_id": null, "initial_veeva_sync": 0, "created_at": "2021-05-04T12:00:37.000000Z", "updated_at": "2021-05-04T12:00:37.000000Z", "deleted_at": null, "reference_uses": 5, "created_at_formatted": "05/04/2021 12:05", "veeva_document": null } } ] } ] } ], "veeva_item": null, "veeva_item_notes": [] }, { "id": 4, "title": null, "section_id": 11, "user_id": 1, "pos": 1, "status": "pending", "parent_id": 2, "revisions_count": 1, "prefix": "1.2.2", "children": [], "section": { "id": 11, "name": "Scientific Statement", "description": null, "pos": 0, "project_id": 1, "parent_id": 10, "children": [] }, "subscription": null, "contents": [ { "id": 4, "item_id": 4, "project_country_id": null, "text": "Also com<a href=\"javascript:void(0);\" id=\"392\" class=\"\">monly known as GBM, the name multiforme is reflective of the extent of genotypic diversity of the tumor.</a>", "clean_text": "Also commonly known as GBM, the name multiforme is reflective of the extent of genotypic diversity of the tumor.", "updated_at": "2023-06-13T16:33:20.000000Z", "commentsCount": 0, "humanReadableUpdatedDate": "13 Jun 2023 at 4:33 pm", "comments": [], "item_content_attachments": [], "subscription": null, "project_country": null, "tags": [ { "id": 567, "item_content_id": 4, "project_tag_id": 20, "user_id": 72, "project_tag": { "id": 20, "project_id": 1, "text": "Aspirational", "style": "emerald", "is_strategic_imperative": 0, "description": null, "created_at": "2023-04-24T12:38:16.000000Z", "updated_at": "2023-04-24T12:38:16.000000Z", "deleted_at": null } } ], "reference_groups": [ { "id": 3, "user_id": 9, "item_content_id": 4, "created_at": "2022-10-18T14:21:28.000000Z", "updated_at": "2022-10-18T14:21:28.000000Z", "deleted_at": null, "references": [] }, { "id": 392, "user_id": 4, "item_content_id": 4, "created_at": "2022-10-18T14:21:35.000000Z", "updated_at": "2022-10-18T14:21:35.000000Z", "deleted_at": null, "references": [] } ] } ], "veeva_item": null, "veeva_item_notes": [] }, { "id": 5, "title": null, "section_id": 11, "user_id": 1, "pos": 2, "status": "pending", "parent_id": 2, "revisions_count": 1, "prefix": "1.2.3", "children": [], "section": { "id": 11, "name": "Scientific Statement", "description": null, "pos": 0, "project_id": 1, "parent_id": 10, "children": [] }, "subscription": null, "contents": [ { "id": 5, "item_id": 5, "project_country_id": null, "text": "The WHO classifies glioblastomas into 3 main categories: glioblastoma isocitrate dehydrogenase (IDH)-mutant, glioblastoma IDH-wildtype, and glioblastoma NOS (not otherwise specified),2 where IDH is an important early biomarker of gliomagenesis.", "clean_text": "The WHO classifies glioblastomas into 3 main categories: glioblastoma isocitrate dehydrogenase (IDH)-mutant, glioblastoma IDH-wildtype, and glioblastoma NOS (not otherwise specified),2 where IDH is an important early biomarker of gliomagenesis.", "updated_at": "2023-06-13T16:33:20.000000Z", "commentsCount": 0, "humanReadableUpdatedDate": "13 Jun 2023 at 4:33 pm", "comments": [], "item_content_attachments": [], "subscription": null, "project_country": null, "tags": [], "reference_groups": [] } ], "veeva_item": null, "veeva_item_notes": [] }, { "id": 6, "title": null, "section_id": 11, "user_id": 1, "pos": 3, "status": "pending", "parent_id": 2, "revisions_count": 1, "prefix": "1.2.4", "children": [], "section": { "id": 11, "name": "Scientific Statement", "description": null, "pos": 0, "project_id": 1, "parent_id": 10, "children": [] }, "subscription": null, "contents": [ { "id": 6, "item_id": 6, "project_country_id": null, "text": "Glioblastomas can be located anywhere in the brain and do not regularly spread outside of the brain.2 In the majority of cases, tumor diameter is between 5-10 cm at diagnosis", "clean_text": "Glioblastomas can be located anywhere in the brain and do not regularly spread outside of the brain.2 In the majority of cases, tumor diameter is between 5-10 cm at diagnosis", "updated_at": "2023-06-13T16:33:20.000000Z", "commentsCount": 0, "humanReadableUpdatedDate": "13 Jun 2023 at 4:33 pm", "comments": [], "item_content_attachments": [], "subscription": null, "project_country": null, "tags": [], "reference_groups": [] } ], "veeva_item": null, "veeva_item_notes": [] }, { "id": 7, "title": null, "section_id": 11, "user_id": 1, "pos": 4, "status": "pending", "parent_id": 2, "revisions_count": 1, "prefix": "1.2.5", "children": [], "section": { "id": 11, "name": "Scientific Statement", "description": null, "pos": 0, "project_id": 1, "parent_id": 10, "children": [] }, "subscription": null, "contents": [ { "id": 7, "item_id": 7, "project_country_id": null, "text": "Primary glioblastomas account for 80% of glioblastomas while secondary types tend to occur in younger patients and carry a better prognosis than primary glioblastomas.", "clean_text": "Primary glioblastomas account for 80% of glioblastomas while secondary types tend to occur in younger patients and carry a better prognosis than primary glioblastomas.", "updated_at": "2023-06-13T16:33:20.000000Z", "commentsCount": 0, "humanReadableUpdatedDate": "13 Jun 2023 at 4:33 pm", "comments": [], "item_content_attachments": [], "subscription": null, "project_country": null, "tags": [], "reference_groups": [] } ], "veeva_item": null, "veeva_item_notes": [] }, { "id": 8, "title": null, "section_id": 11, "user_id": 1, "pos": 5, "status": "pending", "parent_id": 2, "revisions_count": 2, "prefix": "1.2.6", "children": [], "section": { "id": 11, "name": "Scientific Statement", "description": null, "pos": 0, "project_id": 1, "parent_id": 10, "children": [] }, "subscription": null, "contents": [ { "id": 8, "item_id": 8, "project_country_id": null, "text": "The cause of glioblastoma is not known. There are no proven causative links with smoking, diet, cellular phones, environmental exposures or electromagnetic fields. Ionizing radiation is an established risk factor in a minority of cases, and it remains unknown whether the presence of cytomegalovirus and Epstein-Barr Virus in some glioma samples may be causal.", "clean_text": "The cause of glioblastoma is not known. There are no proven causative links with smoking, diet, cellular phones, environmental exposures or electromagnetic fields. Ionizing radiation is an established risk factor in a minority of cases, and it remains unknown whether the presence of cytomegalovirus and Epstein-Barr Virus in some glioma samples may be causal.", "updated_at": "2023-06-13T16:33:20.000000Z", "commentsCount": 0, "humanReadableUpdatedDate": "13 Jun 2023 at 4:33 pm", "comments": [], "item_content_attachments": [], "subscription": null, "project_country": null, "tags": [], "reference_groups": [] } ], "veeva_item": null, "veeva_item_notes": [] } ], "section": { "id": 10, "name": "Communication Objective", "description": null, "pos": 0, "project_id": 1, "parent_id": 9, "children": [ { "id": 11, "name": "Scientific Statement", "description": null, "pos": 0, "project_id": 1, "parent_id": 10, "children": [] } ] }, "subscription": null, "contents": [ { "id": 2, "item_id": 2, "project_country_id": null, "text": "<a href=\"javascript:void(0);\" id=\"1\" class=\"\">Glioblastoma, or glioblastoma multiforme (<strike id=\"1\">GBM</strike>‌), is the most common form of primary malignant brain tumour in adults</a>", "clean_text": "Glioblastoma, or glioblastoma multiforme (GBM‌), is the most common form of primary malignant brain tumour in adults", "updated_at": "2023-11-09T17:54:44.000000Z", "commentsCount": 0, "humanReadableUpdatedDate": "09 Nov 2023 at 5:54 pm", "comments": [], "item_content_attachments": [ { "id": 121, "item_content_id": 2, "attachment_id": 1810, "user_id": 72, "pos": 0, "created_at": "2023-03-15T11:08:47.000000Z", "updated_at": "2023-03-15T11:08:47.000000Z", "deleted_at": null, "attachment": { "id": 1810, "name": "image 1", "user_id": 72, "project_id": 1, "file": "https://sf.polarix.io/6411a73e6a31d.jpg", "type": "image", "is_reference": 0, "contents": null, "pin": 0, "veeva_document_id": null, "initial_veeva_sync": 0, "created_at": "2023-03-15T11:08:46.000000Z", "updated_at": "2023-03-15T11:08:46.000000Z", "deleted_at": null, "reference_uses": 0, "created_at_formatted": "03/15/2023 11:03", "veeva_document": null } } ], "subscription": null, "project_country": null, "tags": [ { "id": 1618, "item_content_id": 2, "project_tag_id": 21, "user_id": 72, "project_tag": { "id": 21, "project_id": 1, "text": "Strategic Imperative 1", "style": "amethyst", "is_strategic_imperative": 0, "description": null, "created_at": "2023-04-24T12:38:36.000000Z", "updated_at": "2023-04-24T12:38:36.000000Z", "deleted_at": null } }, { "id": 1619, "item_content_id": 2, "project_tag_id": 20, "user_id": 72, "project_tag": { "id": 20, "project_id": 1, "text": "Aspirational", "style": "emerald", "is_strategic_imperative": 0, "description": null, "created_at": "2023-04-24T12:38:16.000000Z", "updated_at": "2023-04-24T12:38:16.000000Z", "deleted_at": null } } ], "reference_groups": [ { "id": 1, "user_id": 1, "item_content_id": 2, "created_at": "2022-10-18T14:21:28.000000Z", "updated_at": "2022-10-18T14:21:28.000000Z", "deleted_at": null, "references": [] } ] }, { "id": 3698, "item_id": 2, "project_country_id": 3, "text": "<p>Glioblastoma, or glioblastoma multiforme (GBM‌), is the most common form of primary malignant brain tumor in adults</p>", "clean_text": "Glioblastoma, or glioblastoma multiforme (GBM‌), is the most common form of primary malignant brain tumor in adults", "updated_at": "2023-07-10T12:34:58.000000Z", "commentsCount": 0, "humanReadableUpdatedDate": "10 Jul 2023 at 12:34 pm", "comments": [], "item_content_attachments": [], "subscription": null, "project_country": { "id": 3, "project_id": 1, "country_id": 73, "deadline": null, "auth_code": null, "created_at": "2023-03-31T11:01:38.000000Z", "updated_at": "2023-03-31T11:01:38.000000Z", "deleted_at": null, "deadline_expired": false, "country": { "id": 73, "code": "FR", "name": "France", "prefix": 33, "created_at": "2022-10-18T14:22:06.000000Z", "updated_at": "2022-10-18T14:22:06.000000Z", "deleted_at": null }, "team": { "id": 15, "name": "France", "label": "FR", "project_id": 1, "project_country_id": 3, "team_users": [] } }, "tags": [], "reference_groups": [] } ], "veeva_item": null, "veeva_item_notes": [] }, { "id": 17, "title": null, "section_id": 10, "user_id": 1, "pos": 2, "status": "pending", "parent_id": 1, "revisions_count": 2, "prefix": "1.3", "children": [ { "id": 18, "title": null, "section_id": 11, "user_id": 1, "pos": 0, "status": "pending", "parent_id": 17, "revisions_count": 1, "prefix": "1.3.1", "children": [], "section": { "id": 11, "name": "Scientific Statement", "description": null, "pos": 0, "project_id": 1, "parent_id": 10, "children": [] }, "subscription": null, "contents": [ { "id": 18, "item_id": 18, "project_country_id": null, "text": "<b>Patients</b> with glioblastoma typically present with progressive neurological symptoms over days to weeks", "clean_text": "Patients with glioblastoma typically present with progressive neurological symptoms over days to weeks", "updated_at": "2023-06-13T16:33:20.000000Z", "commentsCount": 0, "humanReadableUpdatedDate": "13 Jun 2023 at 4:33 pm", "comments": [], "item_content_attachments": [], "subscription": null, "project_country": null, "tags": [], "reference_groups": [] } ], "veeva_item": null, "veeva_item_notes": [] }, { "id": 19, "title": null, "section_id": 11, "user_id": 1, "pos": 1, "status": "pending", "parent_id": 17, "revisions_count": 1, "prefix": "1.3.2", "children": [], "section": { "id": 11, "name": "Scientific Statement", "description": null, "pos": 0, "project_id": 1, "parent_id": 10, "children": [] }, "subscription": null, "contents": [ { "id": 19, "item_id": 19, "project_country_id": null, "text": "The most common presenting symptoms are new-onset headache and seizure", "clean_text": "The most common presenting symptoms are new-onset headache and seizure", "updated_at": "2023-06-13T16:33:20.000000Z", "commentsCount": 0, "humanReadableUpdatedDate": "13 Jun 2023 at 4:33 pm", "comments": [], "item_content_attachments": [], "subscription": null, "project_country": null, "tags": [], "reference_groups": [ { "id": 34, 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null, "strokeColor": null, "strokeWidth": null, "nodeIndex": null, "page": 0, "top": 0, "right": 0, "bottom": 0, "left": 0, "created_at_unix": 1688228251, "updated_at_unix": 1688228251, "user": null } ], "attachment": { "id": 5, "name": "Kim 2018", "user_id": 1, "project_id": 1, "file": "https://sf.polarix.io/609137655fc2a.pdf", "type": "pdf", "is_reference": 1, "contents": null, "pin": 0, "veeva_document_id": null, "initial_veeva_sync": 0, "created_at": "2021-05-04T12:00:37.000000Z", "updated_at": "2021-05-04T12:00:37.000000Z", "deleted_at": null, "reference_uses": 5, "created_at_formatted": "05/04/2021 12:05", "veeva_document": null } } ] } ] } ], "veeva_item": null, "veeva_item_notes": [] }, { "id": 20, "title": null, "section_id": 11, "user_id": 1, "pos": 2, "status": "pending", "parent_id": 17, "revisions_count": 2, "prefix": "1.3.3", "children": [], "section": { "id": 11, "name": "Scientific Statement", "description": null, "pos": 0, "project_id": 1, "parent_id": 10, "children": [] }, "subscription": null, "contents": [ { "id": 20, "item_id": 20, "project_country_id": null, "text": "additional common symptoms include focal sympto<a href=\"javascript:void(0);\" id=\"394\" class=\"fresh animate__animated animate__fadeIn\">ms such as neurological deficits, and cognitive and personality changes due to compression and infiltration of normal brain tissue. These may manifest as confusion, memory loss, muscle weakness, visual changes, la</a>nguage deficit, cognitive changes, nausea or vomiting", "clean_text": "additional common symptoms include focal symptoms such as neurological deficits, and cognitive and personality changes due to compression and infiltration of normal brain tissue. These may manifest as confusion, memory loss, muscle weakness, visual changes, language deficit, cognitive changes, nausea or vomiting", "updated_at": "2023-06-13T16:33:20.000000Z", "commentsCount": 0, "humanReadableUpdatedDate": "13 Jun 2023 at 4:33 pm", "comments": [], "item_content_attachments": [], "subscription": null, "project_country": null, "tags": [], "reference_groups": [ { "id": 394, "user_id": 4, "item_content_id": 20, "created_at": "2022-10-18T14:21:35.000000Z", "updated_at": "2022-10-18T14:21:35.000000Z", "deleted_at": null, "references": [ { "id": 446, "attachment_id": 5, "reference_group_id": 394, "user_id": 4, "pos": 418, "created_at": "2021-09-14T18:29:18.000000Z", "updated_at": "2021-09-14T18:29:18.000000Z", "deleted_at": null, "old": true, "annotations": [ { "id": 158590, "attachment_id": 5, "reference_id": 446, "title": null, "bodyValue": null, "motivation": null, "stylesheet_value": null, "source": null, "quadPoints": "[[303,483.496875,549.09243164063,473.896875],[548.6625,482.896875,551.49375,474.496875],[548.6625,483.496875,551.49375,473.896875],[303,471.9,551.47287597656,463.5],[303,472.5,551.47287597656,462.9],[303,460.903125,553.89323730469,452.503125],[303,461.503125,553.89323730469,451.903125],[303,449.896875,510.95551757813,441.496875],[303,450.496875,510.95551757813,440.896875],[510.946875,450.028125,514.10625,444.628125],[510.946875,450.628125,514.10625,444.628125],[514.10625,449.878125,551.35869140625,441.478125],[514.10625,450.478125,551.35869140625,440.878125],[303,438.88125,548.86479492188,430.48125],[303,439.48125,548.86479492188,429.88125],[548.6625,438.88125,551.49375,430.48125],[548.6625,439.48125,551.49375,429.88125],[303,428.484375,548.0958984375,418.884375]]", "inkList": null, "subtype": null, "opacity": null, "strokeColor": null, "strokeWidth": null, "nodeIndex": null, "page": 0, "top": 0, "right": 0, "bottom": 0, "left": 0, "created_at_unix": 1688228253, "updated_at_unix": 1688228253, "user": null } ], "attachment": { "id": 5, "name": "Kim 2018", "user_id": 1, "project_id": 1, "file": "https://sf.polarix.io/609137655fc2a.pdf", "type": "pdf", "is_reference": 1, "contents": null, "pin": 0, "veeva_document_id": null, "initial_veeva_sync": 0, "created_at": "2021-05-04T12:00:37.000000Z", "updated_at": "2021-05-04T12:00:37.000000Z", "deleted_at": null, "reference_uses": 5, "created_at_formatted": "05/04/2021 12:05", "veeva_document": null } } ] } ] } ], "veeva_item": null, "veeva_item_notes": [] }, { "id": 21, "title": null, "section_id": 11, "user_id": 1, "pos": 3, "status": "pending", "parent_id": 17, "revisions_count": 1, "prefix": "1.3.4", "children": [], "section": { "id": 11, "name": "Scientific Statement", "description": null, "pos": 0, "project_id": 1, "parent_id": 10, "children": [] }, "subscription": null, "contents": [ { "id": 21, "item_id": 21, "project_country_id": null, "text": "The presence and degree of peritumoral edema can correlate with symptomatology.", "clean_text": "The presence and degree of peritumoral edema can correlate with symptomatology.", "updated_at": "2023-06-13T16:33:20.000000Z", "commentsCount": 0, "humanReadableUpdatedDate": "13 Jun 2023 at 4:33 pm", "comments": [], "item_content_attachments": [], "subscription": null, "project_country": null, "tags": [], "reference_groups": [] } ], "veeva_item": null, "veeva_item_notes": [] } ], "section": { "id": 10, "name": "Communication Objective", "description": null, "pos": 0, "project_id": 1, "parent_id": 9, "children": [ { "id": 11, "name": "Scientific Statement", "description": null, "pos": 0, "project_id": 1, "parent_id": 10, "children": [] } ] }, "subscription": null, "contents": [ { "id": 17, "item_id": 17, "project_country_id": null, "text": "<a href=\"javascript:void(0);\" id=\"143\" class=\"\">Glioblastomas present almost exclusively in the brain and onset is most commonly signaled by headaches and seizures</a>", "clean_text": "Glioblastomas present almost exclusively in the brain and onset is most commonly signaled by headaches and seizures", "updated_at": "2023-07-04T15:02:10.000000Z", "commentsCount": 0, "humanReadableUpdatedDate": "04 Jul 2023 at 3:02 pm", "comments": [], "item_content_attachments": [], "subscription": null, "project_country": null, "tags": [], "reference_groups": [ { "id": 143, "user_id": 1, "item_content_id": 17, "created_at": "2022-10-18T14:21:31.000000Z", "updated_at": "2022-10-18T14:21:31.000000Z", "deleted_at": null, "references": [ { "id": 168, "attachment_id": 7, "reference_group_id": 143, "user_id": 1, "pos": 147, "created_at": "2021-06-24T13:21:28.000000Z", "updated_at": "2021-06-24T13:21:28.000000Z", "deleted_at": null, "old": true, "annotations": [ { "id": 158581, "attachment_id": 7, "reference_id": 168, "title": null, "bodyValue": null, "motivation": null, "stylesheet_value": null, "source": null, "quadPoints": "[[454.10483870968,812.8064516129,454.11592741935,801.45161290323]]", "inkList": null, "subtype": null, "opacity": null, "strokeColor": null, "strokeWidth": null, "nodeIndex": null, "page": 1, "top": 0, "right": 0, "bottom": 0, "left": 0, "created_at_unix": 1688228251, "updated_at_unix": 1688228251, "user": null } ], "attachment": { "id": 7, "name": "Martinez-Garcia 2018 Clin Transl Oncol 20-22–28", "user_id": 1, "project_id": 1, "file": "https://sf.polarix.io/60913765b7c0e.pdf", "type": "pdf", "is_reference": 1, "contents": null, "pin": 0, "veeva_document_id": null, "initial_veeva_sync": 0, "created_at": "2021-05-04T12:00:37.000000Z", "updated_at": "2021-05-04T12:00:37.000000Z", "deleted_at": null, "reference_uses": 1, "created_at_formatted": "05/04/2021 12:05", "veeva_document": null } } ] } ] } ], "veeva_item": null, "veeva_item_notes": [] }, { "id": 22, "title": null, "section_id": 10, "user_id": 1, "pos": 3, "status": "pending", "parent_id": 1, "revisions_count": 2, "prefix": "1.4", "children": [ { "id": 23, "title": null, "section_id": 11, "user_id": 1, "pos": 0, "status": "pending", "parent_id": 22, "revisions_count": 1, "prefix": "1.4.1", "children": [], "section": { "id": 11, "name": "Scientific Statement", "description": null, "pos": 0, "project_id": 1, "parent_id": 10, "children": [] }, "subscription": null, "contents": [ { "id": 23, "item_id": 23, "project_country_id": null, "text": "Individuals who are suspected to have a glioblastoma should first undergo a full physical and neurological examination.", "clean_text": "Individuals who are suspected to have a glioblastoma should first undergo a full physical and neurological examination.", "updated_at": "2023-06-13T16:33:20.000000Z", "commentsCount": 0, "humanReadableUpdatedDate": "13 Jun 2023 at 4:33 pm", "comments": [], "item_content_attachments": [], "subscription": null, "project_country": null, "tags": [], "reference_groups": [] } ], "veeva_item": null, "veeva_item_notes": [] }, { "id": 24, "title": null, "section_id": 11, "user_id": 1, "pos": 1, "status": "pending", "parent_id": 22, "revisions_count": 1, "prefix": "1.4.2", "children": [], "section": { "id": 11, "name": "Scientific Statement", "description": null, "pos": 0, "project_id": 1, "parent_id": 10, "children": [] }, "subscription": null, "contents": [ { "id": 24, "item_id": 24, "project_country_id": null, "text": "Contrast-enhanced MRI should be included in the initial assessment.3,7 Optimal contrast is 0.1 mmol/kg of gadolinium-chelated contrast agent.", "clean_text": "Contrast-enhanced MRI should be included in the initial assessment.3,7 Optimal contrast is 0.1 mmol/kg of gadolinium-chelated contrast agent.", "updated_at": "2023-06-13T16:33:20.000000Z", "commentsCount": 0, "humanReadableUpdatedDate": "13 Jun 2023 at 4:33 pm", "comments": [], "item_content_attachments": [], "subscription": null, "project_country": null, "tags": [], "reference_groups": [] } ], "veeva_item": null, "veeva_item_notes": [] }, { "id": 25, "title": null, "section_id": 11, "user_id": 1, "pos": 2, "status": "pending", "parent_id": 22, "revisions_count": 1, "prefix": "1.4.3", "children": [], "section": { "id": 11, "name": "Scientific Statement", "description": null, "pos": 0, "project_id": 1, "parent_id": 10, "children": [] }, "subscription": null, "contents": [ { "id": 25, "item_id": 25, "project_country_id": null, "text": "Diagnostic confirmation requires histological evaluation of the tumor, either via fine-needle aspiration biopsy or following initial surgical resection of the glioblastoma.", "clean_text": "Diagnostic confirmation requires histological evaluation of the tumor, either via fine-needle aspiration biopsy or following initial surgical resection of the glioblastoma.", "updated_at": "2023-06-13T16:33:20.000000Z", "commentsCount": 0, "humanReadableUpdatedDate": "13 Jun 2023 at 4:33 pm", "comments": [], "item_content_attachments": [], "subscription": null, "project_country": null, "tags": [], "reference_groups": [] } ], "veeva_item": null, "veeva_item_notes": [] }, { "id": 26, "title": null, "section_id": 11, "user_id": 1, "pos": 3, "status": "pending", "parent_id": 22, "revisions_count": 1, "prefix": "1.4.4", "children": [], "section": { "id": 11, "name": "Scientific Statement", "description": null, "pos": 0, "project_id": 1, "parent_id": 10, "children": [] }, "subscription": null, "contents": [ { "id": 26, "item_id": 26, "project_country_id": null, "text": "The WHO criteria should be used to diagnose glioblastoma, a grade IV tumor, whereby it is defined as an astrocytic infiltrating tumor with one or both of necrosis and microvascular proliferation.", "clean_text": "The WHO criteria should be used to diagnose glioblastoma, a grade IV tumor, whereby it is defined as an astrocytic infiltrating tumor with one or both of necrosis and microvascular proliferation.", "updated_at": "2023-06-13T16:33:20.000000Z", "commentsCount": 0, "humanReadableUpdatedDate": "13 Jun 2023 at 4:33 pm", "comments": [], "item_content_attachments": [], "subscription": null, "project_country": null, "tags": [], "reference_groups": [] } ], "veeva_item": null, "veeva_item_notes": [] }, { "id": 27, "title": null, "section_id": 11, "user_id": 1, "pos": 4, "status": "pending", "parent_id": 22, "revisions_count": 1, "prefix": "1.4.5", "children": [], "section": { "id": 11, "name": "Scientific Statement", "description": null, "pos": 0, "project_id": 1, "parent_id": 10, "children": [] }, "subscription": null, "contents": [ { "id": 27, "item_id": 27, "project_country_id": null, "text": "Differential diagnoses of glioblastoma that should be ruled out include malignancies like chordomas, CNS lymphomas, ependymoma, medulloblastomas, lower grade brain tumors, and cancers that have spread to the brain from other areas, and also non-cancerous conditions such as stroke, brain abscesses, brain bleeds, and cavernous malformations.", "clean_text": "Differential diagnoses of glioblastoma that should be ruled out include malignancies like chordomas, CNS lymphomas, ependymoma, medulloblastomas, lower grade brain tumors, and cancers that have spread to the brain from other areas, and also non-cancerous conditions such as stroke, brain abscesses, brain bleeds, and cavernous malformations.", "updated_at": "2023-06-13T16:33:20.000000Z", "commentsCount": 0, "humanReadableUpdatedDate": "13 Jun 2023 at 4:33 pm", "comments": [], "item_content_attachments": [], "subscription": null, "project_country": null, "tags": [], "reference_groups": [] } ], "veeva_item": null, "veeva_item_notes": [] }, { "id": 28, "title": null, "section_id": 11, "user_id": 1, "pos": 5, "status": "pending", "parent_id": 22, "revisions_count": 2, "prefix": "1.4.6", "children": [], "section": { "id": 11, "name": "Scientific Statement", "description": null, "pos": 0, "project_id": 1, "parent_id": 10, "children": [] }, "subscription": null, "contents": [ { "id": 28, "item_id": 28, "project_country_id": null, "text": "Molecular biomarkers may be used to characterize glioblastomas and to help make treatment decisions. Such markers include the IDH gene mutation status and the methylation status of the promoter of methylguanine methyl transferase (MGMT) gene.", "clean_text": "Molecular biomarkers may be used to characterize glioblastomas and to help make treatment decisions. Such markers include the IDH gene mutation status and the methylation status of the promoter of methylguanine methyl transferase (MGMT) gene.", "updated_at": "2023-06-13T16:33:20.000000Z", "commentsCount": 0, "humanReadableUpdatedDate": "13 Jun 2023 at 4:33 pm", "comments": [], "item_content_attachments": [], "subscription": null, "project_country": null, "tags": [], "reference_groups": [] } ], "veeva_item": null, "veeva_item_notes": [] } ], "section": { "id": 10, "name": "Communication Objective", "description": null, "pos": 0, "project_id": 1, "parent_id": 9, "children": [ { "id": 11, "name": "Scientific Statement", "description": null, "pos": 0, "project_id": 1, "parent_id": 10, "children": [] } ] }, "subscription": null, "contents": [ { "id": 22, "item_id": 22, "project_country_id": null, "text": "<p> The <a href=\"javascript:void(0);\" id=\"391\" class=\"\">diagnostic gold standard</a> for glioblastoma is gadolinium-enhanced magnetic resonance,<a href=\"javascript:void(0);\" id=\"3187\" class=\"\"> imaging (<strike id=\"330\">MRI</strike>)</a></p>", "clean_text": " The diagnostic gold standard for glioblastoma is gadolinium-enhanced magnetic resonance, imaging (MRI)", "updated_at": "2023-08-03T09:23:07.000000Z", "commentsCount": 0, "humanReadableUpdatedDate": "03 Aug 2023 at 9:23 am", "comments": [], "item_content_attachments": [], "subscription": null, "project_country": null, "tags": [], "reference_groups": [ { "id": 391, "user_id": 1, "item_content_id": 22, "created_at": "2022-10-18T14:21:35.000000Z", "updated_at": "2022-10-18T14:21:35.000000Z", "deleted_at": null, "references": [ { "id": 441, "attachment_id": 4, "reference_group_id": 391, "user_id": 1, "pos": 413, "created_at": "2021-07-29T18:10:07.000000Z", "updated_at": "2021-07-29T18:10:07.000000Z", "deleted_at": null, "old": true, "annotations": [ { "id": 158585, "attachment_id": 4, "reference_id": 441, "title": null, "bodyValue": null, "motivation": null, "stylesheet_value": null, "source": null, "quadPoints": "[[70.865625,715.5,307.83801269531,705.9],[70.865625,703.903125,306.75651855469,695.503125],[70.865625,704.503125,306.75651855469,694.903125],[70.865625,692.90625,283.91696777344,684.50625],[70.865625,693.50625,283.91696777344,683.90625],[283.93125,693.046875,287.090625,687.646875],[283.93125,693.646875,287.090625,687.646875],[287.08125,692.896875,307.05622558594,684.496875],[287.08125,693.496875,307.05622558594,683.896875],[70.865625,681.9,307.14144287109,673.5],[70.865625,682.5,307.14144287109,672.9],[70.865625,670.903125,148.54299316406,662.503125],[70.865625,671.503125,148.54299316406,661.903125],[148.5375,671.053125,151.696875,665.653125],[148.5375,671.653125,151.696875,665.653125],[151.6875,670.903125,302.84318847656,662.503125],[151.6875,671.503125,302.84318847656,661.903125],[302.034375,670.903125,304.865625,662.503125],[302.034375,671.503125,304.865625,661.903125],[70.865625,660.496875,304.88598632812,650.896875]]", "inkList": null, "subtype": null, "opacity": null, "strokeColor": null, "strokeWidth": null, "nodeIndex": null, "page": 1, "top": 0, "right": 0, "bottom": 0, "left": 0, "created_at_unix": 1688228253, "updated_at_unix": 1688228253, "user": null } ], "attachment": { "id": 4, "name": "Kang 2020 Cancer Res Treat", "user_id": 1, "project_id": 1, "file": "https://sf.polarix.io/609137653cdd4.pdf", "type": "pdf", "is_reference": 1, "contents": null, "pin": 0, "veeva_document_id": null, "initial_veeva_sync": 0, "created_at": "2021-05-04T12:00:37.000000Z", "updated_at": "2021-05-04T12:00:37.000000Z", "deleted_at": null, "reference_uses": 1, "created_at_formatted": "05/04/2021 12:05", "veeva_document": null } } ] }, { "id": 3187, "user_id": 72, "item_content_id": 22, "created_at": "2023-04-12T12:43:18.000000Z", "updated_at": "2023-04-12T12:43:18.000000Z", "deleted_at": null, "references": [ { "id": 6488, "attachment_id": 2, "reference_group_id": 3187, "user_id": 72, "pos": 6282, "created_at": "2023-04-12T12:43:18.000000Z", "updated_at": "2023-04-12T12:43:18.000000Z", "deleted_at": null, "old": false, "annotations": [ { "id": 150629, "attachment_id": 2, "reference_id": 6488, "title": null, "bodyValue": null, "motivation": "commenting", "stylesheet_value": "body-value-css { font: 12px Helvetica; 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", "clean_text": "Glioblastoma is an aggressive cancer and, even with optimal and timely treatment, overall survival is poor and recurrence rates are high. ", "updated_at": "2023-06-13T16:33:20.000000Z", "commentsCount": 0, "humanReadableUpdatedDate": "13 Jun 2023 at 4:33 pm", "comments": [], "item_content_attachments": [], "subscription": null, "project_country": null, "tags": [], "reference_groups": [] } ], "veeva_item": null, "veeva_item_notes": [] }, { "id": 32, "title": null, "section_id": 11, "user_id": 1, "pos": 1, "status": "pending", "parent_id": 29, "revisions_count": 2, "prefix": "1.5.2", "children": [], "section": { "id": 11, "name": "Scientific Statement", "description": null, "pos": 0, "project_id": 1, "parent_id": 10, "children": [] }, "subscription": null, "contents": [ { "id": 32, "item_id": 32, "project_country_id": null, "text": "Due to high recurrence, frequent follow-ups with repeat imaging are recommended even after completion of treatment.", "clean_text": "Due to high recurrence, frequent follow-ups with repeat imaging are recommended even after completion of treatment.", "updated_at": "2023-06-13T16:33:20.000000Z", "commentsCount": 0, "humanReadableUpdatedDate": "13 Jun 2023 at 4:33 pm", "comments": [], "item_content_attachments": [], "subscription": null, "project_country": null, "tags": [], "reference_groups": [] } ], "veeva_item": null, "veeva_item_notes": [] }, { "id": 31, "title": null, "section_id": 11, "user_id": 1, "pos": 2, "status": "pending", "parent_id": 29, "revisions_count": 2, "prefix": "1.5.3", "children": [], "section": { "id": 11, "name": "Scientific Statement", "description": null, "pos": 0, "project_id": 1, "parent_id": 10, "children": [] }, "subscription": null, "contents": [ { "id": 31, "item_id": 31, "project_country_id": null, "text": "The average survival time for patients with glioblastoma who have received combined treatments of surgery, chemotherapy, and radiotherapy is 14.6 months.", "clean_text": "The average survival time for patients with glioblastoma who have received combined treatments of surgery, chemotherapy, and radiotherapy is 14.6 months.", "updated_at": "2023-06-13T16:33:20.000000Z", "commentsCount": 0, "humanReadableUpdatedDate": "13 Jun 2023 at 4:33 pm", "comments": [], "item_content_attachments": [], "subscription": null, "project_country": null, "tags": [], "reference_groups": [] } ], "veeva_item": null, "veeva_item_notes": [] }, { "id": 33, "title": null, "section_id": 11, "user_id": 1, "pos": 3, "status": "pending", "parent_id": 29, "revisions_count": 1, "prefix": "1.5.4", "children": [], "section": { "id": 11, "name": "Scientific Statement", "description": null, "pos": 0, "project_id": 1, "parent_id": 10, "children": [] }, "subscription": null, "contents": [ { "id": 33, "item_id": 33, "project_country_id": null, "text": "The 5-year survival rate for glioblastoma is extremely low, ranging from reported rates of 5%4 up to 12.1%.", "clean_text": "The 5-year survival rate for glioblastoma is extremely low, ranging from reported rates of 5%4 up to 12.1%.", "updated_at": "2023-06-13T16:33:20.000000Z", "commentsCount": 0, "humanReadableUpdatedDate": "13 Jun 2023 at 4:33 pm", "comments": [], "item_content_attachments": [], "subscription": null, "project_country": null, "tags": [], "reference_groups": [] } ], "veeva_item": null, "veeva_item_notes": [] } ], "section": { "id": 10, "name": "Communication Objective", "description": null, "pos": 0, "project_id": 1, "parent_id": 9, "children": [ { "id": 11, "name": "Scientific Statement", "description": null, "pos": 0, "project_id": 1, "parent_id": 10, "children": [] } ] }, "subscription": null, "contents": [ { "id": 29, "item_id": 29, "project_country_id": null, "text": "<a href=\"javascript:void(0);\" id=\"399\" class=\"\">The average prognosis for glioblastoma is extremely poor, with average overall survival rarely reaching 2 years</a>", "clean_text": "The average prognosis for glioblastoma is extremely poor, with average overall survival rarely reaching 2 years", "updated_at": "2023-07-04T15:02:19.000000Z", "commentsCount": 0, "humanReadableUpdatedDate": "04 Jul 2023 at 3:02 pm", "comments": [], "item_content_attachments": [], "subscription": null, "project_country": null, "tags": [], "reference_groups": [ { "id": 399, "user_id": 1, "item_content_id": 29, "created_at": "2022-10-18T14:21:35.000000Z", "updated_at": "2022-10-18T14:21:35.000000Z", "deleted_at": null, "references": [ { "id": 452, "attachment_id": 21, "reference_group_id": 399, "user_id": 1, "pos": 423, "created_at": "2021-10-29T14:43:28.000000Z", "updated_at": "2021-10-29T14:43:28.000000Z", "deleted_at": null, "old": true, "annotations": [ { "id": 158594, "attachment_id": 21, "reference_id": 452, "title": null, "bodyValue": null, "motivation": null, "stylesheet_value": null, "source": null, "quadPoints": 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"strokeWidth": null, "nodeIndex": null, "page": 1, "top": 0, "right": 0, "bottom": 0, "left": 0, "created_at_unix": 1688228254, "updated_at_unix": 1688228254, "user": null } ], "attachment": { "id": 21, "name": "Microglial cell migration stimulated by ATP and C5a involve distinct molecular mechanisms", "user_id": 1, "project_id": 1, "file": "https://sf.polarix.io/6091422cd0cdc.pdf", "type": "pdf", "is_reference": 0, "contents": null, "pin": 0, "veeva_document_id": null, "initial_veeva_sync": 0, "created_at": "2021-05-04T12:46:36.000000Z", "updated_at": "2021-05-04T12:46:36.000000Z", "deleted_at": null, "reference_uses": 2, "created_at_formatted": "05/04/2021 12:05", "veeva_document": null } } ] } ] } ], "veeva_item": null, "veeva_item_notes": [] } ], "section": { "id": 9, "name": "Pillar", "description": null, "pos": 0, "project_id": 1, "parent_id": null, "children": [ { "id": 10, "name": "Communication Objective", "description": null, "pos": 0, "project_id": 1, "parent_id": 9, "children": [ { "id": 11, "name": "Scientific Statement", "description": null, "pos": 0, "project_id": 1, "parent_id": 10, "children": [] } ] } ] }, "subscription": null, "contents": [ { "id": 1, "item_id": 1, "project_country_id": null, "text": "Glioblastomas are incurable malignant brain tumors with extremely poor prognosis.", "clean_text": "Glioblastomas are incurable malignant brain tumors with extremely poor prognosis.", "updated_at": "2023-06-13T16:33:20.000000Z", "commentsCount": 0, "humanReadableUpdatedDate": "13 Jun 2023 at 4:33 pm", "comments": [], "item_content_attachments": [], "subscription": null, "project_country": null, "tags": [], "reference_groups": [] } ], "veeva_item": null, "veeva_item_notes": [], "subscriptions": [] }, { "id": 34, "title": "Glioblastoma treatment landscape and unmet needs", "section_id": 9, "user_id": 1, "pos": 1, "status": "pending", "parent_id": null, "revisions_count": 4, "prefix": "2", "children": [ { "id": 35, "title": null, "section_id": 10, "user_id": 1, "pos": 0, "status": "pending", "parent_id": 34, "revisions_count": 4, "prefix": "2.1", "children": [ { "id": 36, "title": null, "section_id": 11, "user_id": 1, "pos": 0, "status": "pending", "parent_id": 35, "revisions_count": 1, "prefix": "2.1.1", "children": [], "section": { "id": 11, "name": "Scientific Statement", "description": null, "pos": 0, "project_id": 1, "parent_id": 10, "children": [] }, "subscription": null, "contents": [ { "id": 36, "item_id": 36, "project_country_id": null, "text": "Developing a treatment plan for a patient with glioblastoma should involve a multidisciplinary team including surgical, medical, and radiation oncologists.", "clean_text": "Developing a treatment plan for a patient with glioblastoma should involve a multidisciplinary team including surgical, medical, and radiation oncologists.", "updated_at": "2023-06-13T16:33:21.000000Z", "commentsCount": 0, "humanReadableUpdatedDate": "13 Jun 2023 at 4:33 pm", "comments": [], "item_content_attachments": [], "subscription": null, "project_country": null, "tags": [ { "id": 417, "item_content_id": 36, "project_tag_id": 21, "user_id": 1, "project_tag": { "id": 21, "project_id": 1, "text": "Strategic Imperative 1", "style": "amethyst", "is_strategic_imperative": 0, "description": null, "created_at": "2023-04-24T12:38:36.000000Z", "updated_at": "2023-04-24T12:38:36.000000Z", "deleted_at": null } } ], "reference_groups": [] } ], "veeva_item": null, "veeva_item_notes": [] }, { "id": 37, "title": null, "section_id": 11, "user_id": 1, "pos": 1, "status": "pending", "parent_id": 35, "revisions_count": 2, "prefix": "2.1.2", "children": [], "section": { "id": 11, "name": "Scientific Statement", "description": null, "pos": 0, "project_id": 1, "parent_id": 10, "children": [] }, "subscription": null, "contents": [ { "id": 37, "item_id": 37, "project_country_id": null, "text": "The preferred initial treatment option for glioblastoma is surgical resection but, given the diffuse, invasive and vascular nature of the tumor, surgery alone is not curative. Surgical follow-up with adjuvant chemotherapy and/or radiation is common.", "clean_text": "The preferred initial treatment option for glioblastoma is surgical resection but, given the diffuse, invasive and vascular nature of the tumor, surgery alone is not curative. Surgical follow-up with adjuvant chemotherapy and/or radiation is common.", "updated_at": "2023-06-13T16:33:21.000000Z", "commentsCount": 0, "humanReadableUpdatedDate": "13 Jun 2023 at 4:33 pm", "comments": [], "item_content_attachments": [], "subscription": null, "project_country": null, "tags": [], "reference_groups": [] } ], "veeva_item": null, "veeva_item_notes": [] }, { "id": 38, "title": null, "section_id": 11, "user_id": 1, "pos": 2, "status": "pending", "parent_id": 35, "revisions_count": 1, "prefix": "2.1.3", "children": [], "section": { "id": 11, "name": "Scientific Statement", "description": null, "pos": 0, "project_id": 1, "parent_id": 10, "children": [] }, "subscription": null, "contents": [ { "id": 38, "item_id": 38, "project_country_id": null, "text": "Treatment selection can be guided by the molecular characteristics of the tumor.3 For example, patients with methylated MGMT status derive maximal benefit from temozolomide (TMZ) chemotherapy, such that patients with unmethylated MGMT may be given radiotherapy alone, rather than combined with TMZ.", "clean_text": "Treatment selection can be guided by the molecular characteristics of the tumor.3 For example, patients with methylated MGMT status derive maximal benefit from temozolomide (TMZ) chemotherapy, such that patients with unmethylated MGMT may be given radiotherapy alone, rather than combined with TMZ.", "updated_at": "2023-06-13T16:33:21.000000Z", "commentsCount": 0, "humanReadableUpdatedDate": "13 Jun 2023 at 4:33 pm", "comments": [], "item_content_attachments": [], "subscription": null, "project_country": null, "tags": [], "reference_groups": [] } ], "veeva_item": null, "veeva_item_notes": [] }, { "id": 39, "title": null, "section_id": 11, "user_id": 1, "pos": 3, "status": "pending", "parent_id": 35, "revisions_count": 1, "prefix": "2.1.4", "children": [], "section": { "id": 11, "name": "Scientific Statement", "description": null, "pos": 0, "project_id": 1, "parent_id": 10, "children": [] }, "subscription": null, "contents": [ { "id": 39, "item_id": 39, "project_country_id": null, "text": "Additional medications may be required as supportive treatment, such as high dose steroids (dexamethasone) to reduce vasogenic edema.", "clean_text": "Additional medications may be required as supportive treatment, such as high dose steroids (dexamethasone) to reduce vasogenic edema.", "updated_at": "2023-06-13T16:33:21.000000Z", "commentsCount": 0, "humanReadableUpdatedDate": "13 Jun 2023 at 4:33 pm", "comments": [], "item_content_attachments": [], "subscription": null, "project_country": null, "tags": [], "reference_groups": [] } ], "veeva_item": null, "veeva_item_notes": [] }, { "id": 40, "title": null, "section_id": 11, "user_id": 1, "pos": 4, "status": "pending", "parent_id": 35, "revisions_count": 1, "prefix": "2.1.5", "children": [], "section": { "id": 11, "name": "Scientific Statement", "description": null, "pos": 0, "project_id": 1, "parent_id": 10, "children": [] }, "subscription": null, "contents": [ { "id": 40, "item_id": 40, "project_country_id": null, "text": "Another therapeutic modality which can increase survival when administered concurrently with TMZ is tumor-treating fields (TTF): delivery of low-intensity alternating electric fields to the scalp.", "clean_text": "Another therapeutic modality which can increase survival when administered concurrently with TMZ is tumor-treating fields (TTF): delivery of low-intensity alternating electric fields to the scalp.", "updated_at": "2023-06-13T16:33:21.000000Z", "commentsCount": 0, "humanReadableUpdatedDate": "13 Jun 2023 at 4:33 pm", "comments": [], "item_content_attachments": [], "subscription": null, "project_country": null, "tags": [], "reference_groups": [] } ], "veeva_item": null, "veeva_item_notes": [] } ], "section": { "id": 10, "name": "Communication Objective", "description": null, "pos": 0, "project_id": 1, "parent_id": 9, "children": [ { "id": 11, "name": "Scientific Statement", "description": null, "pos": 0, "project_id": 1, "parent_id": 10, "children": [] } ] }, "subscription": null, "contents": [ { "id": 35, "item_id": 35, "project_country_id": null, "text": "T<a href=\"javascript:void(0);\" id=\"400\" class=\"\">reatment of glioblastoma typically begins with surgical resection,</a> where possible, but surgery alone is not curative, and treatment frequently also includes chemotherapy and radiation therapy. <br>", "clean_text": "Treatment of glioblastoma typically begins with surgical resection, where possible, but surgery alone is not curative, and treatment frequently also includes chemotherapy and radiation therapy. 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"pos": 0, "status": "pending", "parent_id": 41, "revisions_count": 1, "prefix": "2.2.1", "children": [], "section": { "id": 11, "name": "Scientific Statement", "description": null, "pos": 0, "project_id": 1, "parent_id": 10, "children": [] }, "subscription": null, "contents": [ { "id": 42, "item_id": 42, "project_country_id": null, "text": "The current mainstay of treatment involves maximally safe surgical resection followed by radiotherapy with concomitant temozolomide chemotherapy over a 6-week period followed by temozolomide maintenance.", "clean_text": "The current mainstay of treatment involves maximally safe surgical resection followed by radiotherapy with concomitant temozolomide chemotherapy over a 6-week period followed by temozolomide maintenance.", "updated_at": "2023-06-13T16:33:21.000000Z", "commentsCount": 0, "humanReadableUpdatedDate": "13 Jun 2023 at 4:33 pm", "comments": [], "item_content_attachments": [], "subscription": null, "project_country": null, "tags": [], "reference_groups": [] } ], "veeva_item": null, "veeva_item_notes": [] }, { "id": 44, "title": null, "section_id": 11, "user_id": 1, "pos": 1, "status": "pending", "parent_id": 41, "revisions_count": 1, "prefix": "2.2.2", "children": [], "section": { "id": 11, "name": "Scientific Statement", "description": null, "pos": 0, "project_id": 1, "parent_id": 10, "children": [] }, "subscription": null, "contents": [ { "id": 44, "item_id": 44, "project_country_id": null, "text": "The goal of maximal resection surgery is to improve survival while preserving neurological function. Surveillance, Epidemiology, and End Results data suggest that, when compared to biopsy or non-surgical intervention, gross total resection and subtotal resection is correlated with improved survival for patients with glioblastoma.", "clean_text": "The goal of maximal resection surgery is to improve survival while preserving neurological function. Surveillance, Epidemiology, and End Results data suggest that, when compared to biopsy or non-surgical intervention, gross total resection and subtotal resection is correlated with improved survival for patients with glioblastoma.", "updated_at": "2023-06-13T16:33:21.000000Z", "commentsCount": 0, "humanReadableUpdatedDate": "13 Jun 2023 at 4:33 pm", "comments": [], "item_content_attachments": [], "subscription": null, "project_country": null, "tags": [], "reference_groups": [] } ], "veeva_item": null, "veeva_item_notes": [] }, { "id": 45, "title": null, "section_id": 11, "user_id": 1, "pos": 2, "status": "pending", "parent_id": 41, "revisions_count": 1, "prefix": "2.2.3", "children": [], "section": { "id": 11, "name": "Scientific Statement", "description": null, "pos": 0, "project_id": 1, "parent_id": 10, "children": [] }, "subscription": null, "contents": [ { "id": 45, "item_id": 45, "project_country_id": null, "text": "Post-operative radiotherapy aims to deliver radiation at a dose of 50-60 Gy to the tumor and to a margin of radiographically normal tissue to prevent recurrence.", "clean_text": "Post-operative radiotherapy aims to deliver radiation at a dose of 50-60 Gy to the tumor and to a margin of radiographically normal tissue to prevent recurrence.", "updated_at": "2023-06-13T16:33:21.000000Z", "commentsCount": 0, "humanReadableUpdatedDate": "13 Jun 2023 at 4:33 pm", "comments": [], "item_content_attachments": [], "subscription": null, "project_country": null, "tags": [], "reference_groups": [] } ], "veeva_item": null, "veeva_item_notes": [] }, { "id": 46, "title": null, "section_id": 11, "user_id": 1, "pos": 3, "status": "pending", "parent_id": 41, "revisions_count": 1, "prefix": "2.2.4", "children": [], "section": { "id": 11, "name": "Scientific Statement", "description": null, "pos": 0, "project_id": 1, "parent_id": 10, "children": [] }, "subscription": null, "contents": [ { "id": 46, "item_id": 46, "project_country_id": null, "text": "The National Comprehensive Cancer Network (NCCN) guidelines recommend hypo-fractionated radiotherapy in patients with poor performance status, aged >70 years or with methylated MGMT status (with or without chemotherapy).", "clean_text": "The National Comprehensive Cancer Network (NCCN) guidelines recommend hypo-fractionated radiotherapy in patients with poor performance status, aged >70 years or with methylated MGMT status (with or without chemotherapy).", "updated_at": "2023-06-13T16:33:21.000000Z", "commentsCount": 0, "humanReadableUpdatedDate": "13 Jun 2023 at 4:33 pm", "comments": [], "item_content_attachments": [], "subscription": null, "project_country": null, "tags": [], "reference_groups": [] } ], "veeva_item": null, "veeva_item_notes": [] }, { "id": 47, "title": null, "section_id": 11, "user_id": 1, "pos": 4, "status": "pending", "parent_id": 41, "revisions_count": 1, "prefix": "2.2.5", "children": [], "section": { "id": 11, "name": "Scientific Statement", "description": null, "pos": 0, "project_id": 1, "parent_id": 10, "children": [] }, "subscription": null, "contents": [ { "id": 47, "item_id": 47, "project_country_id": null, "text": "Patients’ response to TMZ therapy varies, with many types of glioblastoma being resistant to this type of chemotherapeutic therapy.1 Resistance to TMZ is typically driven by upregulated DNA repair mechanisms and glioblastoma stem-like cells that exhibit a sustained ability to proliferate and differentiate in the presence of TMZ.", "clean_text": "Patients’ response to TMZ therapy varies, with many types of glioblastoma being resistant to this type of chemotherapeutic therapy.1 Resistance to TMZ is typically driven by upregulated DNA repair mechanisms and glioblastoma stem-like cells that exhibit a sustained ability to proliferate and differentiate in the presence of TMZ.", "updated_at": "2023-06-13T16:33:21.000000Z", "commentsCount": 0, "humanReadableUpdatedDate": "13 Jun 2023 at 4:33 pm", "comments": [], "item_content_attachments": [], "subscription": null, "project_country": null, "tags": [], "reference_groups": [] } ], "veeva_item": null, "veeva_item_notes": [] } ], "section": { "id": 10, "name": "Communication Objective", "description": null, "pos": 0, "project_id": 1, "parent_id": 9, "children": [ { "id": 11, "name": "Scientific Statement", "description": null, "pos": 0, "project_id": 1, "parent_id": 10, "children": [] } ] }, "subscription": null, "contents": [ { "id": 41, "item_id": 41, "project_country_id": null, "text": "The current SOC for glioblastoma includes maximal resection surgery, radiation, and TMZ therapy—with TMZ and radiation being commenced within 30 days post-surgery.", "clean_text": "The current SOC for glioblastoma includes maximal resection surgery, radiation, and TMZ therapy—with TMZ and radiation being commenced within 30 days post-surgery.", "updated_at": "2023-06-13T16:33:21.000000Z", "commentsCount": 0, "humanReadableUpdatedDate": "13 Jun 2023 at 4:33 pm", "comments": [], "item_content_attachments": [], "subscription": null, "project_country": null, "tags": [], "reference_groups": [] } ], "veeva_item": null, "veeva_item_notes": [] }, { "id": 48, "title": null, "section_id": 10, "user_id": 1, "pos": 2, "status": "pending", "parent_id": 34, "revisions_count": 1, "prefix": "2.3", "children": [ { "id": 49, "title": null, "section_id": 11, "user_id": 1, "pos": 0, "status": "pending", "parent_id": 48, "revisions_count": 1, "prefix": "2.3.1", "children": [], "section": { "id": 11, "name": "Scientific Statement", "description": null, "pos": 0, "project_id": 1, "parent_id": 10, "children": [] }, "subscription": null, "contents": [ { "id": 49, "item_id": 49, "project_country_id": null, "text": "NCCN guidelines recommend encouraging patients who are unable to receive the SOC and are eligible for clinical trials to join relevant glioblastoma trials.", "clean_text": "NCCN guidelines recommend encouraging patients who are unable to receive the SOC and are eligible for clinical trials to join relevant glioblastoma trials.", "updated_at": "2023-06-13T16:33:21.000000Z", "commentsCount": 0, "humanReadableUpdatedDate": "13 Jun 2023 at 4:33 pm", "comments": [], "item_content_attachments": [], "subscription": null, "project_country": null, "tags": [], "reference_groups": [] } ], "veeva_item": null, "veeva_item_notes": [] }, { "id": 50, "title": null, "section_id": 11, "user_id": 1, "pos": 1, "status": "pending", "parent_id": 48, "revisions_count": 1, "prefix": "2.3.2", "children": [], "section": { "id": 11, "name": "Scientific Statement", "description": null, "pos": 0, "project_id": 1, "parent_id": 10, "children": [] }, "subscription": null, "contents": [ { "id": 50, "item_id": 50, "project_country_id": null, "text": "The dysregulation of cell signaling in glioblastoma has driven the development of therapies that target specific signaling pathways including tumor protein P53, retinoblastoma tumor suppressor and receptor tyrosine kinase.", "clean_text": "The dysregulation of cell signaling in glioblastoma has driven the development of therapies that target specific signaling pathways including tumor protein P53, retinoblastoma tumor suppressor and receptor tyrosine kinase.", "updated_at": "2023-06-13T16:33:21.000000Z", "commentsCount": 0, "humanReadableUpdatedDate": "13 Jun 2023 at 4:33 pm", "comments": [], "item_content_attachments": [], "subscription": null, "project_country": null, "tags": [], "reference_groups": [] } ], "veeva_item": null, "veeva_item_notes": [] }, { "id": 51, "title": null, "section_id": 11, "user_id": 1, "pos": 2, "status": "pending", "parent_id": 48, "revisions_count": 2, "prefix": "2.3.3", "children": [], "section": { "id": 11, "name": "Scientific Statement", "description": null, "pos": 0, "project_id": 1, "parent_id": 10, "children": [] }, "subscription": null, "contents": [ { "id": 51, "item_id": 51, "project_country_id": null, "text": "Glioblastomas are a highly vascularized tumors that expresses large amounts of vascular endothelial growth factor (VEGF). Bevacizumab, a humanized monoclonal antibody to VEGF, improved progression-free survival (PFS) in phase 2 studies but failed to improve overall survival (OS) in phase 3 trials.", "clean_text": "Glioblastomas are a highly vascularized tumors that expresses large amounts of vascular endothelial growth factor (VEGF). Bevacizumab, a humanized monoclonal antibody to VEGF, improved progression-free survival (PFS) in phase 2 studies but failed to improve overall survival (OS) in phase 3 trials.", "updated_at": "2023-06-13T16:33:21.000000Z", "commentsCount": 0, "humanReadableUpdatedDate": "13 Jun 2023 at 4:33 pm", "comments": [], "item_content_attachments": [], "subscription": null, "project_country": null, "tags": [], "reference_groups": [] } ], "veeva_item": null, "veeva_item_notes": [] }, { "id": 52, "title": null, "section_id": 11, "user_id": 1, "pos": 3, "status": "pending", "parent_id": 48, "revisions_count": 2, "prefix": "2.3.4", "children": [], "section": { "id": 11, "name": "Scientific Statement", "description": null, "pos": 0, "project_id": 1, "parent_id": 10, "children": [] }, "subscription": null, "contents": [ { "id": 52, "item_id": 52, "project_country_id": null, "text": "Vaccines targeting glioblastoma are an active form of immunotherapy that have been explored recently. Epidermal growth factor receptor vIII, heat shock protein, and any other tumor-derived antigens are typically loaded into dendritic cells to promote an immune response against glioblastoma.", "clean_text": "Vaccines targeting glioblastoma are an active form of immunotherapy that have been explored recently. Epidermal growth factor receptor vIII, heat shock protein, and any other tumor-derived antigens are typically loaded into dendritic cells to promote an immune response against glioblastoma.", "updated_at": "2023-06-13T16:33:21.000000Z", "commentsCount": 0, "humanReadableUpdatedDate": "13 Jun 2023 at 4:33 pm", "comments": [], "item_content_attachments": [], "subscription": null, "project_country": null, "tags": [], "reference_groups": [] } ], "veeva_item": null, "veeva_item_notes": [] } ], "section": { "id": 10, "name": "Communication Objective", "description": null, "pos": 0, "project_id": 1, "parent_id": 9, "children": [ { "id": 11, "name": "Scientific Statement", "description": null, "pos": 0, "project_id": 1, "parent_id": 10, "children": [] } ] }, "subscription": null, "contents": [ { "id": 48, "item_id": 48, "project_country_id": null, "text": "Given the invasive nature of glioblastoma, the SOC does not effectively mitigate the risk of poor survival outcomes; however, novel therapies are under investigation to address this unmet need", "clean_text": "Given the invasive nature of glioblastoma, the SOC does not effectively mitigate the risk of poor survival outcomes; however, novel therapies are under investigation to address this unmet need", "updated_at": "2023-06-13T16:33:21.000000Z", "commentsCount": 0, "humanReadableUpdatedDate": "13 Jun 2023 at 4:33 pm", "comments": [], "item_content_attachments": [], "subscription": null, "project_country": null, "tags": [], "reference_groups": [] } ], "veeva_item": null, "veeva_item_notes": [] } ], "section": { "id": 9, "name": "Pillar", "description": null, "pos": 0, "project_id": 1, "parent_id": null, "children": [ { "id": 10, "name": "Communication Objective", "description": null, "pos": 0, "project_id": 1, "parent_id": 9, "children": [ { "id": 11, "name": "Scientific Statement", "description": null, "pos": 0, "project_id": 1, "parent_id": 10, "children": [] } ] } ] }, "subscription": null, "contents": [ { "id": 34, "item_id": 34, "project_country_id": null, "text": "Glioblastoma treatment landscape and unmet needs", "clean_text": "Glioblastoma treatment landscape and unmet needs", "updated_at": "2023-06-13T16:33:20.000000Z", "commentsCount": 0, "humanReadableUpdatedDate": "13 Jun 2023 at 4:33 pm", "comments": [], "item_content_attachments": [], "subscription": null, "project_country": null, "tags": [], "reference_groups": [] } ], "veeva_item": null, "veeva_item_notes": [], "subscriptions": [] }, { "id": 53, "title": "Notrealgliovax mechanism of action", "section_id": 9, "user_id": 1, "pos": 2, "status": "pending", "parent_id": null, "revisions_count": 1, "prefix": "3", "children": [ { "id": 58, "title": null, "section_id": 10, "user_id": 1, "pos": 0, "status": "pending", "parent_id": 53, "revisions_count": 2, "prefix": "3.1", "children": [ { "id": 59, "title": null, "section_id": 11, "user_id": 1, "pos": 0, "status": "pending", "parent_id": 58, "revisions_count": 1, "prefix": "3.1.1", "children": [], "section": { "id": 11, "name": "Scientific Statement", "description": null, "pos": 0, "project_id": 1, "parent_id": 10, "children": [] }, "subscription": null, "contents": [ { "id": 59, "item_id": 59, "project_country_id": null, "text": "The migration of vaccines to the lymph nodes is critical for inducing immune responses in patients with glioblastoma.", "clean_text": "The migration of vaccines to the lymph nodes is critical for inducing immune responses in patients with glioblastoma.", "updated_at": "2023-06-13T16:33:21.000000Z", "commentsCount": 0, "humanReadableUpdatedDate": "13 Jun 2023 at 4:33 pm", "comments": [], "item_content_attachments": [], "subscription": null, "project_country": null, "tags": [], "reference_groups": [] } ], "veeva_item": null, "veeva_item_notes": [] }, { "id": 60, "title": null, "section_id": 11, "user_id": 1, "pos": 1, "status": "pending", "parent_id": 58, "revisions_count": 1, "prefix": "3.1.2", "children": [], "section": { "id": 11, "name": "Scientific Statement", "description": null, "pos": 0, "project_id": 1, "parent_id": 10, "children": [] }, "subscription": null, "contents": [ { "id": 60, "item_id": 60, "project_country_id": null, "text": "Dendritic cell vaccines typically are limited in their ability to migrate to the lymph nodes, which may inhibit their efficacy.", "clean_text": "Dendritic cell vaccines typically are limited in their ability to migrate to the lymph nodes, which may inhibit their efficacy.", "updated_at": "2023-06-13T16:33:21.000000Z", "commentsCount": 0, "humanReadableUpdatedDate": "13 Jun 2023 at 4:33 pm", "comments": [], "item_content_attachments": [], "subscription": null, "project_country": null, "tags": [], "reference_groups": [] } ], "veeva_item": null, "veeva_item_notes": [] }, { "id": 61, "title": null, "section_id": 11, "user_id": 1, "pos": 2, "status": "pending", "parent_id": 58, "revisions_count": 1, "prefix": "3.1.3", "children": [], "section": { "id": 11, "name": "Scientific 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"children": [ { "id": 11, "name": "Scientific Statement", "description": null, "pos": 0, "project_id": 1, "parent_id": 10, "children": [] } ] }, "subscription": null, "contents": [ { "id": 58, "item_id": 58, "project_country_id": null, "text": "<p><a href=\"javascript:void(0);\" id=\"2580\" class=\"\">Notrealgliovax readily migrates to the lymph nodes, which is critical for inducing an immune response against the glioblastoma.</a></p>", "clean_text": "Notrealgliovax readily migrates to the lymph nodes, which is critical for inducing an immune response against the glioblastoma.", "updated_at": "2023-06-13T16:33:21.000000Z", "commentsCount": 0, "humanReadableUpdatedDate": "13 Jun 2023 at 4:33 pm", "comments": [], "item_content_attachments": [ { "id": 122, "item_content_id": 58, "attachment_id": 1811, "user_id": 72, "pos": 0, "created_at": "2023-03-15T13:58:49.000000Z", "updated_at": "2023-03-15T13:58:49.000000Z", "deleted_at": null, "attachment": { "id": 1811, "name": "image", "user_id": 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"prefix": "3.2", "children": [ { "id": 55, "title": null, "section_id": 11, "user_id": 1, "pos": 0, "status": "pending", "parent_id": 54, "revisions_count": 3, "prefix": "3.2.1", "children": [], "section": { "id": 11, "name": "Scientific Statement", "description": null, "pos": 0, "project_id": 1, "parent_id": 10, "children": [] }, "subscription": null, "contents": [ { "id": 55, "item_id": 55, "project_country_id": null, "text": "Microglia cells are the resident immune cells of the brain. They survey the CNS environment and respond to pathogens, toxins, and tumors by presenting antigens required for a complete antigen-specific CD T-cell response in the brain", "clean_text": "Microglia cells are the resident immune cells of the brain. They survey the CNS environment and respond to pathogens, toxins, and tumors by presenting antigens required for a complete antigen-specific CD T-cell response in the brain", "updated_at": "2023-06-13T16:33:21.000000Z", "commentsCount": 0, "humanReadableUpdatedDate": "13 Jun 2023 at 4:33 pm", "comments": [], "item_content_attachments": [], "subscription": null, "project_country": null, "tags": [], "reference_groups": [] } ], "veeva_item": null, "veeva_item_notes": [] }, { "id": 56, "title": null, "section_id": 11, "user_id": 1, "pos": 1, "status": "pending", "parent_id": 54, "revisions_count": 2, "prefix": "3.2.2", "children": [], "section": { "id": 11, "name": "Scientific Statement", "description": null, "pos": 0, "project_id": 1, "parent_id": 10, "children": [] }, "subscription": null, "contents": [ { "id": 56, "item_id": 56, "project_country_id": null, "text": "Notrealgliovax is developed by isolating microglia cells from patients with glioblastoma, loading the cells with tumor 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"project_id": 1, "parent_id": 10, "children": [] }, "subscription": null, "contents": [ { "id": 69, "item_id": 69, "project_country_id": null, "text": "<a href=\"javascript:void(0);\" id=\"2654\" class=\"fresh animate__animated animate__fadeIn\">Treatment with notrealgliovax in recurrent glioblastoma resulted in a mOS of 24 months and estimated median PFS of 8.6 months in patients aged 18-50.</a>", "clean_text": "Treatment with notrealgliovax in recurrent glioblastoma resulted in a mOS of 24 months and estimated median PFS of 8.6 months in patients aged 18-50.", "updated_at": "2023-06-13T16:33:21.000000Z", "commentsCount": 0, "humanReadableUpdatedDate": "13 Jun 2023 at 4:33 pm", "comments": [], "item_content_attachments": [], "subscription": null, "project_country": null, "tags": [], "reference_groups": [ { "id": 2654, "user_id": 1, "item_content_id": 69, "created_at": "2023-03-27T13:59:18.000000Z", "updated_at": "2023-03-27T13:59:18.000000Z", "deleted_at": null, "references": [ { 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"section_id": 10, "user_id": 1, "pos": 0, "status": "pending", "parent_id": 71, "revisions_count": 1, "prefix": "5.1", "children": [ { "id": 73, "title": null, "section_id": 11, "user_id": 1, "pos": 0, "status": "pending", "parent_id": 72, "revisions_count": 1, "prefix": "5.1.1", "children": [], "section": { "id": 11, "name": "Scientific Statement", "description": null, "pos": 0, "project_id": 1, "parent_id": 10, "children": [] }, "subscription": null, "contents": [ { "id": 73, "item_id": 73, "project_country_id": null, "text": "<a href=\"javascript:void(0);\" id=\"1865\" class=\"fresh animate__animated animate__fadeIn\">One of the primary objectives of the phase 2 trial was to assess the safety and tolerability of notrealgliovax</a>‌ in patients with glioblastoma by evaluating the occurrence of AEs and clinically significant changes in vital signs and laboratory tests.", "clean_text": "One of the primary objectives of the phase 2 trial was to assess the safety and tolerability of 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"status": "pending", "parent_id": 72, "revisions_count": 2, "prefix": "5.1.3", "children": [], "section": { "id": 11, "name": "Scientific Statement", "description": null, "pos": 0, "project_id": 1, "parent_id": 10, "children": [] }, "subscription": null, "contents": [ { "id": 76, "item_id": 76, "project_country_id": null, "text": "<a href=\"javascript:void(0);\" id=\"5385\" class=\"\">There were no treatment discontinuations due to AEs and no treatment-related deaths</a>. WHO", "clean_text": "There were no treatment discontinuations due to AEs and no treatment-related deaths. 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however, these reactions were easily managed.", "clean_text": "Following notrealgliovax administration, 25% of patients experienced injection site reactions; however, these reactions were easily managed.", "updated_at": "2023-06-13T16:33:21.000000Z", "commentsCount": 0, "humanReadableUpdatedDate": "13 Jun 2023 at 4:33 pm", "comments": [], "item_content_attachments": [], "subscription": null, "project_country": null, "tags": [], "reference_groups": [] } ], "veeva_item": null, "veeva_item_notes": [] }, { "id": 79, "title": null, "section_id": 11, "user_id": 1, "pos": 1, "status": "pending", "parent_id": 77, "revisions_count": 1, "prefix": "5.2.2", "children": [], "section": { "id": 11, "name": "Scientific Statement", "description": null, "pos": 0, "project_id": 1, "parent_id": 10, "children": [] }, "subscription": null, "contents": [ { "id": 79, "item_id": 79, "project_country_id": null, "text": "<p>Using the recommended techniques for the administration of notrealgliovax can help to reduce injection-site reactions. <strike id=\"103\">WHO</strike></p>", "clean_text": "Using the recommended techniques for the administration of notrealgliovax can help to reduce injection-site reactions. WHO", "updated_at": "2023-11-23T16:40:13.000000Z", "commentsCount": 0, "humanReadableUpdatedDate": "23 Nov 2023 at 4:40 pm", "comments": [], "item_content_attachments": [], "subscription": null, "project_country": null, "tags": [], "reference_groups": [] }, { "id": 6045, "item_id": 79, "project_country_id": 3, "text": "L’utilisation des techniques recommandées pour l’administration de notrealgliovax peut aider à réduire les réactions au site d’injection. QUI", "clean_text": "L’utilisation des techniques recommandées pour l’administration de notrealgliovax peut aider à réduire les réactions au site d’injection. QUI", "updated_at": "2023-09-13T17:49:28.000000Z", "commentsCount": 0, "humanReadableUpdatedDate": "13 Sep 2023 at 5:49 pm", "comments": [], "item_content_attachments": [], "subscription": null, "project_country": { "id": 3, "project_id": 1, "country_id": 73, "deadline": null, "auth_code": null, "created_at": "2023-03-31T11:01:38.000000Z", "updated_at": "2023-03-31T11:01:38.000000Z", "deleted_at": null, "deadline_expired": false, "country": { "id": 73, "code": "FR", "name": "France", "prefix": 33, "created_at": "2022-10-18T14:22:06.000000Z", "updated_at": "2022-10-18T14:22:06.000000Z", "deleted_at": null }, "team": { "id": 15, "name": "France", "label": "FR", "project_id": 1, "project_country_id": 3, "team_users": [] } }, "tags": [], "reference_groups": [] } ], "veeva_item": null, "veeva_item_notes": [] }, { "id": 81, "title": null, "section_id": 11, "user_id": 1, "pos": 2, "status": "pending", "parent_id": 77, "revisions_count": 2, "prefix": "5.2.3", "children": [], "section": { "id": 11, "name": "Scientific Statement", "description": null, "pos": 0, "project_id": 1, "parent_id": 10, "children": [] }, "subscription": null, "contents": [ { "id": 81, "item_id": 81, "project_country_id": null, "text": "Following administration, if patients experience pain, redness, or itching, it is recommended that patients apply a cold compress at the injection site and take an over-the-counter pain reliever for pain or an antihistamine for itching.", "clean_text": "Following administration, if patients experience pain, redness, or itching, it is recommended that patients apply a cold compress at the injection site and take an over-the-counter pain reliever for pain or an antihistamine for itching.", "updated_at": "2023-06-13T16:33:21.000000Z", "commentsCount": 0, "humanReadableUpdatedDate": "13 Jun 2023 at 4:33 pm", "comments": [], "item_content_attachments": [], "subscription": null, "project_country": null, "tags": [], "reference_groups": [ { "id": 5388, "user_id": 1, "item_content_id": 81, "created_at": "2023-07-12T12:30:34.000000Z", "updated_at": "2023-07-12T12:30:34.000000Z", "deleted_at": null, "references": [ { "id": 9826, "attachment_id": 21, "reference_group_id": 5388, "user_id": 1, "pos": 9554, "created_at": "2023-07-12T12:30:34.000000Z", "updated_at": "2023-07-12T12:30:34.000000Z", "deleted_at": null, "old": false, "annotations": [ { "id": 161412, "attachment_id": 21, "reference_id": 9826, "title": null, "bodyValue": null, "motivation": "commenting", "stylesheet_value": "body-value-css { font: 12px Helvetica; 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", "clean_text": "If bleeding at the injection site occurs, pressure should be applied to the site until the bleeding has stopped and the site should be covered with an adhesive bandage. 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